**LECTURE TITLE:** Reproductive System: Anatomy, Physiology, and Pathophysiology

**OVERVIEW**

* Learning objectives:
+ Understand the anatomy and physiology of the reproductive system
+ Recognize pathophysiological processes in the reproductive system
+ Apply diagnostic and therapeutic strategies for reproductive disorders
+ Evaluate clinical presentations and complications of reproductive diseases
* Estimated lecture time: 75 minutes

**INTRODUCTION (5-10 minutes)**

Reproductive health is a critical aspect of overall well-being, affecting individuals across all age groups. The reproductive system encompasses both male and female anatomy, physiology, and pathophysiology. Understanding the complex interactions within this system is essential for diagnosing and managing reproductive disorders.

Key questions to be answered:

* What are the essential components of the reproductive system?
* How do hormonal imbalances impact reproductive function?
* What are the common causes of infertility and reproductive failure?

Historical context: The concept of "humoral medicine" was introduced in ancient Greece, emphasizing the importance of balance between "hot" and "cold" bodily fluids. Later, the discovery of hormones by Charles-Édouard Brown-Séquard in 1904 revolutionized our understanding of reproductive physiology.

**MAIN CONTENT**

### Anatomy and Physiology

* **Definitions and terminology:**
+ Male reproductive system: penis, testes, epididymis, vas deferens, seminal vesicles, prostate gland
+ Female reproductive system: vulva, vagina, cervix, uterus, ovaries, fallopian tubes
+ Spermatogenesis: 70-80 days; hormone-dependent
* **Pathophysiology/mechanisms:**
+ Hormonal regulation: gonadotropins (FSH, LH), sex hormones (estrogen, progesterone)
+ Mechanism of ovulation: estrogen-induced follicular growth, LH surge, ovum release
* **Clinical presentations:**
+ Infertility: reduced fertility, amenorrhea, abnormal bleeding patterns
+ Polycystic ovary syndrome (PCOS): insulin resistance, hyperandrogenism, anovulatory cycles
* **Diagnostic approach:**
+ Physical examination: pelvic exam, scrotal exam
+ Laboratory tests: hormone levels, semen analysis, ultrasound
* **Treatment strategies:**
+ Contraception: hormonal and barrier methods
+ Fertility treatment: IVF, IUI, intrauterine insemination
+ Hormone replacement therapy (HRT): for menopausal symptoms, PCOS management
* **Complications and prognosis:**
+ Ovarian torsion: twisting of the ovary, potentially fatal if not treated promptly
+ Uterine rupture: catastrophic complication during pregnancy or childbirth

**CLINICAL CASES**

1. A 35-year-old woman presents with primary amenorrhea. Physical examination reveals no pubic hair, and laboratory tests reveal elevated FSH levels.
* Discussion points: possible causes (Turner syndrome, congenital adrenal hyperplasia), diagnosis, treatment options
2. A 40-year-old man presents with reduced fertility and a history of testicular trauma. Physical examination reveals a painful scrotum.
* Discussion points: possible causes (testicular torsion, epididymal obstruction), diagnosis, treatment options
3. A 28-year-old woman presents with irregular menstrual cycles and hirsutism. Physical examination reveals acne and male pattern baldness.
* Discussion points: possible causes (PCOS, insulin resistance), diagnosis, treatment options

**SUMMARY & KEY POINTS**

Top 10 must-remember facts:

1. The reproductive system is a complex interplay of hormones, anatomy, and physiology.
2. Hormonal imbalances can lead to reproductive disorders.
3. Diagnostic approaches include physical examination, laboratory tests, and imaging studies.
4. Treatment strategies include contraception, fertility treatment, hormone replacement therapy, and surgical interventions.
5. Complications such as ovarian torsion and uterine rupture require prompt attention.

Quick review bullets:

* Spermatogenesis: 70-80 days; hormone-dependent
* Ovulation mechanism: estrogen-induced follicular growth, LH surge, ovum release
* PCOS: insulin resistance, hyperandrogenism, anovulatory cycles

**PRACTICE QUESTIONS**

1. A 25-year-old woman presents with primary amenorrhea and elevated FSH levels. What is the most likely diagnosis?
A) Turner syndrome
B) Congenital adrenal hyperplasia
C) PCOS
D) Hypothalamic amenorrhea

Answer: A) Turner syndrome

2. A 30-year-old man presents with reduced fertility and a history of testicular trauma. Physical examination reveals a painful scrotum. What is the most likely diagnosis?
A) Testicular torsion
B) Epididymal obstruction
C) Varicocele
D) Hydrocele

Answer: A) Testicular torsion

3. A 30-year-old woman presents with irregular menstrual cycles and hirsutism. Physical examination reveals acne and male pattern baldness. What is the most likely diagnosis?
A) PCOS
B) Insulin resistance
C) Hypothyroidism
D) Cushing's syndrome

Answer: A) PCOS
Last modified: Sunday, 9 November 2025, 5:47 PM